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Birth Cohorts in Israel

There is a growing awareness of the long-term health effects of intrauterine and early life exposures to environmental pollutants, and their role as contributing factors to the development of illness and disease later in life. Because of the lag that often exists between the time of exposure to environmental pollutants and the emergence of diseases such as cancer, cardiovascular disease, obesity, impaired neuro-cognitive development, diabetes and fertility problems later in life, ecological studies in epidemiology can provide only weak evidence of causality. Birth cohort studies, which examine environmental exposures and health outcomes over time, have become a vital tool in providing stronger evidence of causal relationships. This evidence can then support   policy interventions to reduce the exposures and improve public health.
 

Over the years, the Environment and Health Fund has supported the establishment of several birth cohorts in Israel which are investigating the impact of environmental exposures. This support has provided the infrastructure for long-term monitoring, collection and storage of information and samples, and the examination of the relationship between chronic diseases and environmental exposures in Israel.

 

Cohort Name First enrollment Status Location Principal investigator Envinromental pollutants measured Contact (email)
Environment and Health Fund – Ichilov – Shamir Medical Center (Assaf Harofeh) (EHF-AHI) Cohort 2013 Children follow-up Assaf Harofeh Medical Center / Soraski Medical Center Prof. Mati Berkovitch/ Prof. Dror Mendel PBDEs, PCBs, Phthalates (planned) mberkovitch@asaf.health.gov.il
Environment, Mother and Child Cohort 2013 Children follow-up Hadassah Medical Center Prof. Ronit Calderon Margalit Phthalates, Organophosphates, Cotinine ronitcm@gmail.com
Twins Cohort- Sheba MC 2015 Completed Sheba Medical Center Dr. Ronit Machtinger Phthalates, Phenols and alternatives, Parabens, Triclosan, Oxybenzone mmachtin@gmail.com
IVF Cohort- Gertner Institute 2015 Completed Assaf Harofeh Medical Center Prof. Liat Lerner Organophosphorus flame retardants (OPFRs) LiatL@gertner.health.gov.il
Rambam – Shamir Medical Center (Assaf Harofeh) (AHR) Cohort 2016 Enrolling Rambam Medical Center / Assaf Harofeh Medical Center Prof. Mati Berkovitch/ Prof. Ido Solt/ Prof. Amalia Levy Heavy metals, BTEX mberkovitch@asaf.health.gov.il
Negev Pregnancy Cohort (NPC) 2017 Enrollment completed Ben Gurion University Dr. Tamar Wainstock Organophosphates, Heavy metals wainstoc@bgu.ac.il
Haifa Pregnancy Cohort – Maccabi HS 2019 Enrolling Haifa district Dr. Hagai Levine Heavy metals, BTEX, Cotinine, PAHs (planned) hagai.levine@gmail.com